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Cellulitis risk factors: skin breaks, swelling, weight and warning signs

Cellulitis is a common bacterial infection of the deeper layers of the skin. Here is what the Centers for Disease Control and Prevention (CDC) and MedlinePlus say about who is more likely to get it, the signs to watch for, and when to get medical attention right away.

Last reviewed: By the uncovermyrisk.com editorial team Educational only, not medical advice.

When to get help right away.The CDC says to seek medical attention immediately if the red area of the skin spreads quickly or you develop a fever or chills (CDC).

What cellulitis is

Cellulitis is a common bacterial infection of the deeper layers of the skin. It causes redness, swelling, and pain in the infected area. If untreated, cellulitis can spread and cause serious health problems (CDC).

Different bacteria can cause cellulitis. Group A strep (streptococcal) bacteria are the most common cause (MedlinePlus). The bacteria enter your body when you get an injury such as a bruise, burn, surgical cut, or wound (MedlinePlus). In general, people cannot catch cellulitis from others (CDC).

Who is more likely to get cellulitis

Anyone can get cellulitis, but some factors can increase the risk of getting this infection (CDC).

Infections or injuries that break the skin

The CDC lists these risk factors, which allow bacteria to get through the skin (CDC):

For many people who get cellulitis, experts don't know how the bacteria get into the body (CDC).

Other health factors

Other factors that increase risk for cellulitis include being overweight and chronic edema (CDC). Chronic edema is when limbs, like feet, legs, hands, or arms, stay swollen (CDC).

Repeat infections

People who've had multiple cellulitis infections below the knee should be checked for fungal infections, and any infections found should be treated (CDC).

Signs of cellulitis

Generally, skin affected by cellulitis is painful, red, swollen, tender to the touch, and warm. The skin may look pitted, like the peel of an orange, and blisters may appear on the affected skin. Some people may also develop fever and chills (CDC). MedlinePlus also lists swollen glands or lymph nodes, and says the skin may blister and scab over (MedlinePlus).

Cellulitis can appear anywhere on the body, but it's most common on the feet and legs (CDC).

Complications

Complications from cellulitis are uncommon but can include serious infections (CDC):

Cellulitis can also cause thrombophlebitis (swelling in a vein due to a blood clot) (CDC). Sepsis is the body's extreme response to an infection (MedlinePlus); see sepsis risk factors for who is most at risk and its warning signs.

Diagnosis and treatment

Healthcare providers typically diagnose cellulitis by looking at the affected skin during a physical examination. Blood or other lab tests aren't usually needed (CDC). Healthcare providers use oral antibiotics to treat most cellulitis infections, and IV antibiotics can be used to treat more serious infections. Keeping the affected limb (arm or leg) elevated can help decrease swelling and speed up recovery (CDC).

Common questions

Is cellulitis contagious?

In general, people cannot catch cellulitis from others (CDC).

Where on the body does cellulitis usually appear?

It can appear anywhere on the body, but it's most common on the feet and legs (CDC).

Why does swelling in the legs matter?

The CDC lists chronic edema, when limbs stay swollen, as a factor that increases risk for cellulitis. Lymphedema and a coronary artery bypass graft are two conditions that can cause it (CDC).

Sources

  1. Centers for Disease Control and Prevention. About Cellulitis (group A strep). Page dated August 5, 2025; read November 7, 2026 from the web.archive.org copy of October 26, 2026. www.cdc.gov/group-a-strep/about/cellulitis.html
  2. MedlinePlus (National Library of Medicine). Cellulitis. Health topic page, last updated June 25, 2025, accessed November 7, 2026. medlineplus.gov/cellulitis.html
  3. MedlinePlus (National Library of Medicine). Sepsis. Health topic page, last updated November 13, 2023, accessed November 7, 2026. medlineplus.gov/sepsis.html

Written and maintained by the uncovermyrisk.com editorial team. We do not have a medical reviewer; every claim links to its primary source above. Last reviewed: 2026-11-07. Spotted an error? See About.